Hi-CSCi: A high-throughput screening platform for discovering novel cancer drugs
Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression.
Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion.
Prostate cancer is the second leading cause of cancer-related deaths in males in the United States, and the vast majority of those deaths result from metastatic cancer. We have developed a cell line that could serve as a cell-based model to discover novel drugs targeting lethal prostate cancer cells*.
Cell lines have been generated and characterized.
*Zhang S, Wang X, Osunkoya AO, Chen Z, Iqbal S, Müller S, Chen Z, Josson S, Coleman IM, Nelson PS, Wang R, Shin DM, Marshall FF, Kucuk O, Chung LWK, Zhau HE, Wu D. EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. Oncogene, 30:4941-4952, 2011.